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Huntington

Huntington’s Disease is a devastating, degenerative brain
disorder for which there is, at present, no effective treatment or
cure. It slowly diminishes the affected individual’s ability to
walk, think, talk and reason. Eventually, the person with the
disease becomes totally dependent upon others for his or her
Unfortunately, the trait is dominant, and there is no such
thing as a carrier.Either you have it, or you don't, though some
people don't find out that they have the gene until they have
children.The disorder affects males and females equally and
crosses all ethnic and racial boundaries.Each child of a person
withthe abnormality has a 50/50 chance of inheriting the fatal
gene. Everyone who carries the gene will develop the disease.
In 1993, A genetic marker was discovered which localised
the Huntington’s disease gene to an area close to the tip of the
short arm of chromosome four.The gene itself causes
horrendous problems.At one end of the gene, a pattern of three
DNA bases (CAG), repeats itself in all cases. In normal
individuals, this triplet repetition occurs between 11 and 29
times. In people with Huntington’s disease, the repeat occurs
over and over again, from 40 times to more than 80.This
abnormal number of repeated sequences prevent the gene from
functioning properly.The gene repetitions lead to the repeated
amino acid on the protein produced by the gene called
huntingtin.The repeated amino acid (glutamine) changes the
way the protein works with all of the other proteins.Huntingtin
with the repeatedglutamine sequences seizes and keeps hold of
the important proteins in the brain and body.With all of this
disorder going on throughout the body, all of the other proteins
can't perform their regular role.
This is a disease that can be very draining on families:
emotionally, physically and economically.Though the disease is

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